As we age, our NAD+ levels decrease, and this is linked to aging. The rate of decline is greater than the body's natural ability to replace NAD+. Studies on old mice have shown that some markers of aging can be reversed by giving them NAD+ precursors.
Why is NAD+ so critical?
NAD+ is important for three main functions in the body: producing energy, activating "longevity genes" called SIRTUINS, and repairing DNA. SIRTUINS cannot work without enough NAD+. NAD+ also helps repair broken DNA strands, which maintains the integrity of the genetic code and protects against mutations.
What causes NAD+ levels to fall?
NAD+ levels decrease because NAD+ is used by enzymes like SIRTUINS, DNA-repair enzymes, and aggressively by CD38 for calcium balancing and immune function response. CD38 is the greatest destroyer of NAD+ in the body, driven Inflammatory cytokines and Senescent cells. Eventually, more NAD+ is used up than can be replenished, contributing to the over-all decline that is
experienced with aging.
It is now clear that supporting NAD+ levels is important for promoting good health, especially as we age.